Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of Indicaxanthin

Herein, we assessed the effect of full native peptide amyloid-beta (Aβ) (1-42) and its fragments (25-35 35-25) on tissue transglutaminase (TG2) isoforms (TG2-Long TG2-Short) expression levels olfactory ensheathing cells (OECs). Vimentin glial fibrillary acid protein (GFAP) were also studied. The pre-treatment with indicaxanthin from Opuntia ficus-indica fruit TG2 isoforms, cell viability, total reactive oxygen species (ROS), superoxide anion (O2−), apoptotic pathway activation was assessed. Nestin cyclin D1 evaluated. Our findings highlight that OECs exposure to Aβ(1-42) induced an increase in a different pattern isoforms. Indicaxanthin reduced overexpression, modulating It ROS O2− production, GFAP levels, inhibiting activation. levels. data demonstrated stimulated self-renewal through reparative activity played by TG2. They suggest Aβ might modify conformation modulate conformation, stimulating neural regeneration Alzheimer’s disease.